This is really hard to answer. We know that for whatever reason (perhaps genetic, as I’ve written about this topic on another site) some people are more susceptible to liver damage then others. Having said that I’m sure that BSL has sold thousands of bottles of Super DMZ , and this is the only case of liver cholestasis reported to date. Which leads me to suggest a couple things – first, be wary of abusing multiple “methyl” stacked products like this (Metha-Quad Xtreme is another bad one by BSL). And if you do, you should be an experienced user that uses something like NAC or T/UDCA as a support supplement.