Anti-inflammatory treatments have an obvious potential as insulin-sensitizing therapies. However, current attempts have not been overly successful. A widespread therapeutic approach to modulating the immune system involves thiazolidinediones (TZDs). TZDs are PPAR-γ agonists that have well-known insulin-sensitizing effects in the clinical setting. TZDs have direct effects in adipocytes, liver, macrophages, skeletal muscle, Treg cells, and the CNS; all of these tissue-specific effects can contribute to overall systemic insulin sensitization. These drugs also have potent anti-inflammatory actions on immune cells and contribute to improvements in insulin resistance in T2DM patients  . For example, they can promote the M2 polarization state of macrophages and enhance Treg cell differentiation and function. However, TZDs only partially correct insulin resistance. Although TZDs have a robust effect in lowering glucose levels in T2DM subjects, they show a relatively modest effect in improving insulin sensitivity. In addition, TZDs are associated with several adverse effects, including weight gain, edema, and heart disease  .
I know all diabetics can respond differently but this is what I do and you would have to find the foods you enjoy. I buy all organic and when I get up before I juice I have organic asparagus spears like people eat carrots. I will eat 2 to 5 depending on size. Also I always have avocado at my house and I may have some of that as that gives your body fat and fiber to slow down absorption. This has been my routine as I’m a creature of habit when it works great.
I use these ingredients every morning. 1 carrot, 1 celery, 1/3 cucumber, ginger, 1/2 lemon, 1 clementine, 1/4 to 1/2 apple, 1 pineapple slice, if I have broccoli or cauliflower I juice the stems as I eat the tops. I know its a lot of natural sugar but my sugar is always perfect 2 hours after. I vary how much fruit depending on size. Once thats done I add the 1 tsp. tumeric and drink up. I cant even tell you I never get sick and I have more energy than I know what to do with. I am in the service business and am around sick people and germs and eating right is huge in my book. My A1C is perfect all the time. My doctor told me I should write a book about food with diabetics and she would endorse me. : -) healthy living and my disease are my passion. Good luck I hope this helps. Lori