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have you had a chance to listen to the latest investor’s conference by ESPR?
pretty enlightening concerning LDL-c theory… they have put together a great team of PIs. seems that both inflammation and LDL lowering are key to reducing cardiovascular risks. Fourier results not has stellar because trial only 2 years long. Explanation was also provided by experts as to why CETP inhibitors trials failed.
This gives me confidence in ESPR chances of success, considering CVOT trial is 5 years long and for patients with no background of statins (statin intolerant).
Also, it seems that the combination pill will be their go-to drug. Pricing will be in the range of Crestor Lipitor before parents expires. ESPR thinks target population is 12M in US and an additional 12M in Europe.
What do you think they will do now? Partner for Europe and Japan? Remain independent, or sell the company? and when do you think these choices will mature?

Re your vitamin D levels, which your last blood test showed were too low (you want to be between 60-80 ng/mL), since you are lucky enough to be living in the Phoenix area, — if you are not already doing this — please get outside for at least a half hour sometime between 12pm and 2pm and get some sunshine on your skin (no sunscreen!). You can wear a hat and put sunscreen on your face to prevent wrinkling and age spots, but leave at least your arms and legs bare and sunbathe. If even after taking 4,000 IU per day and getting some sun for a couple of months, you are still not in the 60-80 ng/mL range, your genetic inheritance may — like mine — have resulted in poor absorption of vitmain D, so that you need more than the typical person. Please have another blood test run to check you vitamin D levels in another 2 months.
I will look into recommendations for a good endocrinologist in Phoenix. You might check with Martha Grout, MD. She is in Scottsdale, here’s a link to her website. I do not know her personally, but she is a member of the Institute for Functional Medicine –a very good sign, the doctors involved with the IFM are both better informed and more open to integrative medicine. She may know of me, but will certainly know of my husband, Dr. Joe Pizzorno–he has been on the IFM board for 20+ years, is one of their Linus Pauling Award recipients, and served as Chair of the IFM Board for a number of years. Here s a link to Dr. Grout’s website: http://
Re being insurance poor – I am hoping that Dr. Grout will still be able to be helpful. I cannot know your financial situation, but nothing is as important as your health. Please consider investing in your health if you possibly can.
Lastly, re bio-identical hormone replacement. I am on BHRT myself–have been for about 10 years now — and I believe this would also be very helpful for you. Dr. Grout does offer BHRT. To learn more, you could read Dr. Wright’s excellent book about it — explains absolutely everything you need to know about BHRT. Has a horrible title, though – Stay Young & Sexy with BHRT (Smart Publications — http://-/books/stay-young-sexy-with-bio-identical-hormone-replacement-the-science-exp/ )
Please keep me posted on how you are doing. And don’t hesitate to get in touch if I can be helpful.

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