Intralesional steroid treatment alopecia areata

Smaller keloids can be flattened with a more concentrated kenalog (steroid) injection. Some doctors will add 5-fluorouracil to the mix. In my experience it is better to debulk or complete cut out larger keloids (like your 2x2cm one) and then use modalities to stop the keloid from coming back. These modalities are application of pressure with more kenalog injections as needed or radiation treatments to scar line. Topical steroid mostly that which is impregnated into a tape that is applied to the skin can soften a hypertrophic scar or prevent a keloid from coming back. In my experience the topical steroid alone will not clear a keloid that has already formed.

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We hypothesize that the fibroblast, or the myofibroblast, or both are the key cells responsible for keloid and hypertrophic scar formation. These cell types produce the bulk of extracellular matrix components during normal wound healing. In fact, experimental evidence suggests that hy­pertrophic scars and keloids result from excessive amounts of collagen and proteoglycan production or from lack of remodeling of these moie­ties.''-" We also hypothesize that wound tension is a major factor in the formation of both the hypertrophic scar and the keloid, which occurs sec­ondary to direct biochemical changes induced by this mechanical factor. Most likely these changes are a direct result of the effect of wound tension on the metabolism of the fibroblast or myofibroblast. Fibroblasts have been shown to increase cell proliferation in response to mechanical tension in Mechanical stretch alone has been shown to raise the number of myofibroblasts in mouse dermis in Presumably, mechanical ten­sion is also responsible for a positive balance in the collagen and proteo­glycan production-degradation cycle in the wound healing under exces­sive tension. We are currently studying the effects of mechanical tension on wound healing at the biochemical level. The cause-effect relationship between hypertrophic scar and keloid formation as well as other etiologic factors, such as the age and race of the patient, remain more highly spec­ulative and are not discussed here.

Intralesional steroid treatment alopecia areata

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