Steroid-induced osteoporosis (SIOP) is osteoporosis arising due to use of glucocorticoids (steroid hormones) - analogous to Cushing's syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Bisphosphonates are beneficial in reducing the risk of vertebral fractures.  Some professional guidelines recommend prophylactic calcium and vitamin D supplementation in patients who take the equivalent of more than 30 mg hydrocortisone ( mg of prednisolone), especially when this is in excess of three months.   The use of thiazide diuretics, and gonadal hormone replacement has also been recommended, with the use of calcitonin, bisphosphonates, sodium fluoride or anabolic steroids also suggested in refractory cases.  Alternate day use may not prevent this complication. 
In the US, Dexamethasone (dexamethasone systemic) is a member of the drug class glucocorticoids and is used to treat Addison's Disease , Adrenal Insufficiency , Adrenocortical Insufficiency , Adrenogenital Syndrome , Allergic Rhinitis , Ankylosing Spondylitis , Aphthous Ulcer , Aspiration Pneumonia , Asthma , Asthma - acute , Atopic Dermatitis , Bronchopulmonary Dysplasia , Bursitis , Cerebral Edema , Chorioretinitis , Croup , Cushing's Syndrome , Dermatitis Herpetiformis , Eczema , Epicondylitis - Tennis Elbow , Erythroblastopenia , Evan's Syndrome , Gouty Arthritis , Hemolytic Anemia , Hypercalcemia of Malignancy , Idiopathic Thrombocytopenic Purpura , Inflammatory Bowel Disease , Inflammatory Conditions , Iridocyclitis , Iritis , Juvenile Rheumatoid Arthritis , Keratitis , Leukemia , Loeffler's Syndrome , Lymphoma , Meningitis - Haemophilus influenzae , Meningitis - Listeriosis , Meningitis - Meningococcal , Meningitis - Pneumococcal , Mountain Sickness / Altitude Sickness , Multiple Myeloma , Multiple Sclerosis , Mycosis Fungoides , Nausea/Vomiting - Chemotherapy Induced , Neurosarcoidosis , Pemphigus , Plaque Psoriasis , Psoriasis , Psoriatic Arthritis , Pulmonary Tuberculosis , Rheumatoid Arthritis , Sarcoidosis , Seborrheic Dermatitis , Shock , Synovitis , Systemic Lupus Erythematosus , Thrombocytopenia , Toxic Epidermal Necrolysis , Transverse Myelitis , Tuberculous Meningitis , Ulcerative Colitis and Uveitis - Posterior .