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Testing for IgE was performed in approximately 60 patients in clinical trials who experienced moderate to severe infusion reactions or in whom mast cell activation was suspected. Seven of these patients tested positive for Fabrazyme (agalsidase beta) -specific IgE antibodies or had a positive skin test to Fabrazyme (agalsidase beta) . Patients who have had a positive skin test to Fabrazyme (agalsidase beta) , or who have tested positive for Fabrazyme (agalsidase beta) -specific IgE antibodies in clinical trials with Fabrazyme have been re-challenged [see Clinical Studies , WARNINGS AND PRECAUTIONS and DOSAGE AND ADMINISTRATION ].

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